NPC1L1 and diabetes mellitus: A large-scale meta-analysis of genetic association studies has shown that exposure to LDL-C-lowering genetic variants near NPC1L1 and PCSK9 genes is associated with an increased risk of type 2 diabetes, with a 1.19 to 2.42-fold increase in overall diabetes risk per 1 mmol/L decrease in LDL-C (4).