TNF and neoplasm: As shown in Fig. 2A, inflammatory response and cell cycle-related pathways such as oxidative phosphorylation, DNA repair, TNFα signaling via NFκB, allograft rejection and Myc-targets-v1 were significantly activated in S1 subtype, while tumor-related pathways of Mitotic spindle, Hedgehog signaling, epithelial mesenchymal transition (EMT), and Wnt-β-catenin signaling were activated in S3 subtype.