Since ATX was first discovered as a cell motility factor, it has been found to be expressed by a wide variety of tumor cells, including those in breast cancer, glioblastoma, hepatocellular carcinoma, neuroblastoma, non-small-cell lung cancer, prostate cancer, renal cell carcinoma and thyroid carcinoma (Yuelling & Fuss, 2008). The gene discussed is ENPP2; the disease is neoplasm.