ENPP2 and neoplasm: Many studies have shown that overexpression of ENPP2 inhibits the ability of ferroptosis to prevent the development of hypoxia/reoxygenation (H/R) injury (Fang, Shen & Liao, 2023) and can enhance tumor cell spreading, migration, and metastasis through LPAR1 (Auciello et al., 2019; Lin et al., 2019).