By loading melatonin, MLT‐MLP exhibited an important role in regulating the metabolic reprogramming of inflammatory macrophages, thereby inhibiting NLRP3 inflammasome activation and facilitating the phenotypic shift of macrophages from the M1 to the M2 phenotype, ultimately resulting in significant therapeutic effects in acute gouty arthritis (Scheme 1C,D). This evidence concerns the gene NLRP3 and gout.