Gout is the most common inflammatory arthritis caused by the deposition of MSU crystals in the joints and periarticular tissues.[2, 4, 33] The main anti‐inflammatory medications currently available are NSAIDs, colchicine, and corticosteroids, however, all of these drugs have severe side effects.[2] Following the discovery that NLRP3 inflammation activation and IL‐1β release mediate the acute gout initiation, drugs targeting IL‐1β have been developed. The gene discussed is NLRP3; the disease is gout.