Herein, the fabrication of high‐entropy MXene TiVNbMoC3Tx (T = surface terminations) with a layer of polydopamine is reported, followed by immobilization of a phthalocyanine‐based fluorophore for imaging and the peptide sequence QRHKPREGGGSC for targeting the epidermal growth factor receptor (EGFR) overexpressed in cancer cells. The gene discussed is EGFR; the disease is cancer.