MAGE family member A1 (MAGEA1) is a member of MAGEA gene family and has tumor promoting activity in melanoma, which may be due to the activation of P‐C‐JUN or ERK‐MAPK signaling pathway.[12] Studies have shown that MAGEA1 can inhibit the transcription of p53 in medulloblastoma and esophageal squamous cell carcinoma.[13, 14] However, whether MAGEA1 can regulate p53 transcriptional function in melanoma remains unknown. This evidence concerns the gene TP53 and esophageal squamous cell carcinoma.