High mobility group box 1 (HMGB1) is a non histone chromatin related protein widely distributed in eukaryotic cells, which can be transferred to the extracellular environment as a risk warning protein, activate the immune response, and participate in the regulation of inflammation and cancer progression.[15] In melanoma, HMGB1 can be secreted through p53, NF‐κB stimulates melanoma proliferation, metastasis and increased drug resistance.[16] However, whether HMGB1 can regulate the stemness of melanoma cells through MLLT3 interaction remains unknown. Here, MLLT3 is linked to cancer.