As a reader of m5C, YBX1 plays an important role in the occurrence and development of tumors.[18] Some studies suggest that silencing YBX1 expression significantly inhibits the stemness of melanoma stem cells,[19] and NSUN2 regulates the proliferation and migration of uveal melanoma cells by mediating RNA m5C modification.[20] However, how MLLT3 regulates m5C modification remains unclear. The gene discussed is MLLT3; the disease is melanoma.