HMGB1 and cancer: YBX1, as a reader, regulates the apparent modification of m5C.[34] In addition, the modification of m5C is closely related to the occurrence and development of cancer.[35, 36] P53 is a powerful tumor suppressor, which can inhibit tumor growth in a variety of ways.[37] Our results showed that MLLT3 interacted with HMGB1 to inhibit its entry into the nucleus.