demonstrated that nuclear Nrf2 activity in laryngeal carcinoma is regulated by SENP3 after cisplatin‐induced oxidative stress,[31] but in this study, we found that SENP6, rather than SENP3, effectively bound to Nrf2 and deconjugate SUMO2 from the Nrf2 protein. Here, SUMO2 is linked to laryngeal carcinoma.