found that deSUMOylation of Nrf2 in laryngeal carcinoma is involved in the inhibition of the Nrf2/ARE pathway after cisplatin‐induced ROS stress.[31] However, whether and how Nrf2 SUMOylation influences neuronal fate in the brain during ischemic stroke remains poorly understood. This evidence concerns the gene NFE2L2 and laryngeal carcinoma.