SOX2 and neoplasm: Additionally, previous studies suggested that c‐Jun could upregulate several transcription factors that regulate tumor stemness and dormancy, particularly during the epithelial mesenchymal transition, such as SOX9, SOX2,[45] Snail and Slug.[46] Thus, we performed a ChIP assay to determine if nuclear TRAF4 increases c‐Jun's transcriptional activity on these downstream genes.