However, our findings still could not completely exclude the influence of cytoplasmic TRAF4 on tumor development, because studies have shown that cytoplasmic TRAF4 could promote metastasis by activating TGF‐β, TrkA, and other cytoplasmic signals.[36, 37] Indeed, TRAF4 nuclear accumulation should not be viewed as a separate molecular event. Here, TRAF4 is linked to neoplasm.