These DEPs and DEPPs in the BrM/Glioma group were closely linked to one of the major regulators of both BrM and glioma: the PI3K‐Akt signaling pathway.[3, 27] However, the upstream PI3K‐Akt pathways showed significant differences between those two types of brain tumors, which has rarely been discussed before (Figure3A). This evidence concerns the gene AKT1 and central nervous system cancer.