GRB2 and central nervous system cancer: Methionine aminopeptidases 1 (METAP1) was reported to interfere with the PI3K/AKT/mTOR signaling axis by promoting PI3K inhibition in breast cancer.[35] Additionally, NSUN2 can activate PI3K‐Akt signaling by inducing the m5C modification of growth factor receptor‐bound protein 2 (GRB2).[36] In glioma samples, only one phosphosite (PRKCG_S330) exhibited dramatically elevated expression in the Glioma/Glioma‐NAT group.