AKT1 and brain neoplasm: These DEPs and DEPPs in the BrM/Glioma group were closely linked to one of the major regulators of both BrM and glioma: the PI3K‐Akt signaling pathway.[3, 27] However, the upstream PI3K‐Akt pathways showed significant differences between those two types of brain tumors, which has rarely been discussed before (Figure3A).