However, in certain instances, various non‐catalytic subunits, such as DDOST, were required to form stable complexes with the substrate during the process.[12] We used CPTAC, an online proteomic database, to investigate the expression levels of STT3A, STT3B, and DDOST between colon cancer tissues and paired normal tissues, and found that the 3 proteins were upregulated in colon cancer tissues (Figure 5C). Here, DDOST is linked to malignant colon neoplasm.