ACADM, an enzyme involved in fatty acid metabolism, does not directly regulate cellular proliferation, invasion, or metastasis.[13] Therefore, we hypothesized that the regulation of ACADM expression via N‐glycosylation modification of CTSD at residue 263 may influence the invasiveness and metastasis of CRC cells through mechanisms associated with fatty acid metabolism. The gene discussed is CTSD; the disease is colorectal carcinoma.