Importantly, in a CMT167 tumor‐bearing mouse model, we found that GP@Gel Nap‐T promoted mitochondrial oxidative stress (i.e., increased ROS and mitochondrial superoxide, decreased MMP and GSH), DAMPs release (i.e., CRT, HMGB1, ATP, and HSP70), DC recruitment (i.e., CD45+CD11c+), and DC maturation (i.e., CD80+CD86+) within tumor tissues. This evidence concerns the gene CD86 and neoplasm.