Herein, we designed a smart peptide hydrogelator Nap–Phe–Phe–Phe–Lys–Ser–Thr–Gly–Gly–Lys–Ala–Pro–Arg–OH (Nap‐T) that was responsive to pyruvate kinase M2 (PKM2), aiming to improve chemo‐immunotherapy of NSCLC through localized codelivery and controlled release of PTX and GDC0919. This evidence concerns the gene PKM and non-small cell lung carcinoma.