Upon injection of GP@Gel Nap‐T into the NSCLC tumor model, the overexpressed PKM2 in tumor triggers the disassembly of GP@Gel Nap‐T (i.e., 1 PKM2‐triggered disassembly) to release PTX and GDC0919 (i.e., 2 Release of drugs). Here, PKM is linked to neoplasm.