Simultaneously, Treg‐specifical CXCR6 knockout mice (CXCR6[flox/flox], FOXP3YFP‐Cre[KI/+], CXCR6‐KO PJI) were also used to establish S. aureus PJI mouse model (Figure S8c,d, Supporting Information). ScRNA‐seq analysis on knee synovial immune cells from negative control mice (Sham‐operated, CXCR6[+/+], FOXP3YFP‐Cre[KI/+), PJI mice (CXCR6[+/+], FOXP3YFP‐Cre[KI/+, 35d), and CXCR6‐KO PJI (35d) mice demonstrated that lymphocyte populations were classified into twelve distinct subpopulations (Figure 6a,b; Figure S8f,g, Supporting Information). The gene discussed is CXCR6; the disease is juvenile polyposis syndrome.