Growing evidence from various study demonstrates that CXCR6‐deficency mice is a practical, successful and sustainable animal model for the establishment of different pathogen models (such as lung infection, tumor, IBD, inflammatory arthritis) in different time points (from 7d to 80d).[43, 91, 92, 93, 94] As to these studies, the CXCR6‐deficient mice seldom exhibited impairments or significant adverse phenotypes under standard protocol. Here, CXCR6 is linked to inflammatory bowel disease.