CXCL16 and neoplasm: Actually, chemokines and their receptors has been extensive applied as therapeutical target, primarily focusing on tumor immunotherapy.[86, 87] The inhibition of CXCR2 in pancreatic tumors prevented metastatic spreading by enhancing the T cell response and improving sensitivity to anti‐PD‐1 therapy.[88, 89] This is also supported by our finding that targeting the CXCR6 in Treg, the specific receptor of CXCL16, can effectively prevent the progression of S. aureus PJI.