So far, given the specific function of CXCR6+ T cells and their small proportion within peripheral immune organs and peripheral blood, there have been no reports indicating that targeting them with an anti‐CXCR6 mouse antibody or through CXCR6 KO would result in severe systemic side effects.[47, 92] Although CXCR6 deficiency may lead to defective T cell migration and retention in peripheral tissues,[91, 97, 98] the functional relevance of CXCR6 in T cell biology within the PJI microenvironment remains unknown. This evidence concerns the gene CXCR6 and juvenile polyposis syndrome.