FAP and osteoarthritis: During cellular senescence, sustained growth arrest and changes in protein expression are accompanied by the SASP.[42] In osteoarthritis, single‐cell sequencing identified key pathogenic chondrocyte subpopulations characterized by high FAP expression alongside SASP‐related genes.[20] Similarly, our experiments demonstrated that FAP expression paralleled that of senescence markers, such as P21, in the gingival cell senescence model.