FAP and periodontitis: FAP is a serine protease that promotes disease progression by regulating extracellular matrix degradation and inflammation.[31] We performed bilateral periodontal local injections of FAP‐selective small‐molecule inhibitors (FAPi, 40 μg kg−1) or vehicle controls (DMSO) in periodontitis and wild‐type mice to test whether inhibiting FAP activity could alleviate periodontitis progression.[14] We used Ac‐Gly‐BoroPro as the FAPi, which could selectively inhibit FAP relative to other prolyl peptidases at submicromolar concentrations and with higher biosafety according to previous studies.[8, 14, 32]