To further simulate oxidative stress–induced ROS elevation and subsequent cellular senescence observed in periodontitis, while aligning with the activation of the related pathways identified in FAP+ fibroblasts from our previous findings, we opted to induce senescence in H‐HGFs by H2O2 treatment.[28] H‐HGFs were exposed to varying concentrations of H2O2 (0–400 μm) for 12 h and 100 μm H2O2 for different durations (0–24 h) to determine the optimal concentration and exposure time for H2O2‐induced senescence. The gene discussed is FAP; the disease is periodontitis.