FAP and periodontitis: We utilized the latest genome‐wide association study (GWAS) data to conduct Mendelian randomization (MR) analysis (Figure 1A) to explore the potential causal relationship between FAP and periodontitis.[22] As 5 single nucleotide polymorphisms (SNPs) were selected as instrumental variables for FAP levels, the inverse variance weighting (IVW) analysis revealed that elevated FAP levels were significantly associated with periodontitis (odds ratio = 1.096, 95% confidence interval = 1.011–1.188, p = 0.027) (Figure 1B).