SPP1 and neoplasm: Among these subsets of macrophages, Mac_c06_SPP1 (SPP1+, PLIN2+) exhibits a distinct malignant phenotype, manifested in its high expression of the degradation of the extracellular matrix (ECM)‐related genes (MMP14, MMP12, and MMP9), enhanced ability to promote angiogenesis, and weakened ability to phagocytose tumor cells (Figure 5E,F).