It is worth noting that naïve CD8+ T cell maturation requires antigen presentation with cDC1 and their proximity in location to occur a co‐stimulation event.[16] However, in our ICC samples, cDC1 rarely infiltrates the tumor side of the leading‐edge area and mostly aggregates in the tertiary lymphoid structures (TLS) of the non‐tumor area, so as CD8+ naïve T cells (Figure 4F; Figure S5A, Supporting Information). Here, MPPE1 is linked to neoplasm.