More importantly, the differentially expressed genes (DEGs) are also identified from the RNA‐Seq dataset upon the activation of HSCs by FGF19 and compared the DEGs in matched primary and metastatic mRNA samples from patients with CRC liver metastasis (CRCLM), it is found that the ANGPTL4 gene is significantly associated with HSCs activation. This evidence concerns the gene ANGPTL4 and colorectal carcinoma.