A recent report demonstrated that CRC‐derived exosomal miR‐181a‐5p activates HSCs and hence facilitates CRCLM.[12] Previously, we reported that liver metastasis can be facilitated by the interplay between CRC cells and HSCs through the vascular endothelial growth factor (VEGF)‐interleukin 6 (IL6)‐signal transducer and activator of transcription 3 (STAT3) axis.[13] However, besides the CRC cells, VEGF can also be released by various other cell types, including endothelial cells, macrophages, platelets, keratinocytes, and renal mesangial cells. The gene discussed is STAT3; the disease is colorectal carcinoma.