Using single‐cell RNA sequencing (scRNA‐Seq) and clinical samples, fibroblast growth factor‐19 (FGF19, rodent FGF15) is found to mediate a significant interaction between CRC cells and cancer‐associated fibroblasts (CAFs), activating the hepatic stellate cells (HSCs)‐to‐CAFs differentiation. This evidence concerns the gene FGF19 and cancer.