ANGPTL4 and neoplasm: More importantly, the knockdown of ANGPTL4 inhibits lipids production, proliferation, and invasion in lung adenocarcinoma cells.[46] Cancer cells within the tumor microenvironment undergo rapid proliferation, survival, migration, and invasion through altered lipid metabolism.[47] In this study, we found that ANGPTL4 promotes CRC cell migration, suggesting that the underlying mechanism may be associated with the modulation of lipid metabolism.