More importantly, the knockdown of ANGPTL4 inhibits lipids production, proliferation, and invasion in lung adenocarcinoma cells.[46] Cancer cells within the tumor microenvironment undergo rapid proliferation, survival, migration, and invasion through altered lipid metabolism.[47] In this study, we found that ANGPTL4 promotes CRC cell migration, suggesting that the underlying mechanism may be associated with the modulation of lipid metabolism. This evidence concerns the gene ANGPTL4 and cancer.