HSCs deposit collagen and fibronectin, forming a scaffold that facilitates the extravascular micro‐metastases of cancer cells.[7, 9] Activated HSCs also trigger the formation of neutrophil extracellular traps in the liver that serve as metastatic niches.[10] In addition, studies have shown that activated HSCs increase the expression of fibroblast activation protein alpha (FAPα) and the secretion of chemokine CXCL5. The gene discussed is FAP; the disease is cancer.