A recent report demonstrated that CRC‐derived exosomal miR‐181a‐5p activates HSCs and hence facilitates CRCLM.[12] Previously, we reported that liver metastasis can be facilitated by the interplay between CRC cells and HSCs through the vascular endothelial growth factor (VEGF)‐interleukin 6 (IL6)‐signal transducer and activator of transcription 3 (STAT3) axis.[13] However, besides the CRC cells, VEGF can also be released by various other cell types, including endothelial cells, macrophages, platelets, keratinocytes, and renal mesangial cells. Here, IL6 is linked to colorectal carcinoma.