Compared to quiescent cells, growth‐promoting pathways, including mTOR and MAPK, have higher activity in senescent cells, and the role of the MAPK pathway in senescent cells is to accelerate aging rather than proliferation.[35] Moreover, excessive activation of the p38 MAPK pathway leads to T cell aging and immune deficiency in humans.[36] These results suggest that in advanced‐age pregnancies, high PD‐1 expression may cause Treg cell senescence through MAPK overactivation. This evidence concerns the gene MTOR and Immunodeficiency.