GC and depressive symptom measurement: We observed elevated levels of VDBP protein in both plasma and postmortem dorsolateral prefrontal cortex tissues of patients with MDD, as well as in PrL microglia from mice with LPS‐induced depression‐like symptoms.[3, 4] Considering that liver is reported to be the main source of VDBP production in plasma,[5] we further explored the presence of VDBP in brain‐derived extracellular vesicles.