By contrast, neuron‐specific knockdown of megalin in AAV–VDBP mice followed by CUMS induction, which we term the AAV–VDBP + AAV–siMegalin + CUMS group, showed significant amelioration of depression‐like behaviors as compared with AAV–VDBP + CUMS mice (Figure 5d–g). Here, GC is linked to major depressive disorder.