PRL and major depressive disorder: Brain regions showing significantly increased VDBP protein in CUMS‐susceptible mice included the hippocampus (p < 0.001), PrL (p < 0.001), hypothalamus (p < 0.01), and nucleus accumbens core (AcbC) (p < 0.01) (Figure 1i–k), suggesting that VDBPs in core regions of emotion circuits are associated with chronic‐stress‐induced depression‐like behaviors.