GC and depressive disorder: Importantly, AAV–VDBP + CUMS group mice showed exacerbation of depression‐like behaviors, including significantly decreased SPT scores (Figure 2j) (p < 0.05), increased immobility times in the TST (p < 0.05) (Figure 2l) and in FST (p < 0.05) (Figure 2m), suggesting that the targeted overexpression of VDBP aggravates the CUMS‐induced depressive phenotypes, further revealing the importance of VDBP in the pathogenesis of depression.