Compared with control mice injected with saline, VDBP‐protein‐treated mice showed significant differences in the SPT (p < 0.05) (Figure 2v), OFT (p < 0.05) (Figure 2w), TST (p < 0.05) (Figure 2x), and FST (p < 0.001) (Figure 2y), suggesting that exogenous VDBP can induce depression‐like behaviors in mice. The gene discussed is GC; the disease is major depressive disorder.