The present study is the first to provide evidence that MG‐derived VDBP is highly expressed in the PrL region of CUMS‐susceptible mice, which supports the cross‐species findings of our previous research[4] and provides a basis for further work focusing on the causal mechanism of the interaction between MG‐derived VDBP and neurons in the development of depression. Here, PRL is linked to major depressive disorder.