DX could promote neuroinflammation or inhibit inflammatory responses of microglia.[17, 18, 19] DX‐treated primary mouse microglia or BV2 cells as in vitro stressed cell models were widely used in depression research.[20, 21, 22] DX significantly increased the VDBP expression at mRNA level (Figure S3a, Supporting Information) (p < 0.01 or p < 0.05), protein level (p < 0.05 or p < 0.001) (Figure S3b, Supporting Information), and secretion level (both p < 0.05) (Figure S3c, Supporting Information) in both BV2 and primary MG. This evidence concerns the gene GC and depressive symptom measurement.