BDNF and noise induced hearing loss: developed a minimally invasive middle ear delivery system using a brain‐derived neurotrophic factor (BDNF)‐poly‐(dl‐lactic acid‐co‐glycolic acid) (PLGA)‐loaded hydrogel, which effectively reversed cochlear synaptopathy and restored hearing function in a noise‐induced hearing loss (NIHL) mouse model, highlighting the potential of targeted synaptic repair for treating sensorineural deafness.[66] Furthermore, MatrigelTM is one of the most widely used natural polymers in the cultivation of cochlear organoids, owing to its ability to closely mimic the native extracellular matrix environment.