Following the refinement of CRISPR results using a local smoothen model,[20] our CRISPR tiling scan unveiled the pivotal roles of two regions, P1 (K67–S74 in the matrix domain) and P2 (K135–K169 comprising the intermembrane space domain) within COX4I1, that is critical for leukemia cell survival (Figure 5B). The gene discussed is COX4I1; the disease is leukemia.