COX4I1 and leukemia: To delineate the regions essential for leukemia cell survival within COX4I1, we employed a high‐resolution gene tiling scan technique, which identifies functional domains within a protein through CRISPR‐induced mutagenesis.[19] To accomplish this, we constructed a CRISPR library targeting every position harboring an NGG protospacer adjacent motif (PAM) within the coding exons of COX4I1 (Figure5A; SourceData S6 and Figure S1C, Supporting Information).