CCND3 and leukemia: Employing the MAGeCK algorithm,[9] this focused CRISPR screen unveiled COX4I1 (encoding Cytochrome c oxidase subunit 4 isoform 1) as a top essential gene in leukemia cells, alongside five previously reported leukemia essential genes (Figure 1B, red; MYC, RPS6, CCND3, GAB2, and AURKB).