KMT2A and leukemia: Notably, while our study primarily focused on AML cell models with MLL gene rearrangements (Molm13, MV4‐11, and THP‐1), analysis of the DepMap CRISPR screen database indicates that targeting COX4I1 may have broader implications across multiple AML subtypes (Figure S7, Supporting Information), potentially paving the way for therapies against diverse forms of leukemia.