MT-ND6 and Leber hereditary optic neuropathy: These results were consistent with those in cells bearing a deafness-associated tRNAPhe 593T>C or LHON-associated tRNAAla 5587T>C mutations (4, 22) and but contrast with the upregulation of ubiquitination-dependent mitophagy but downregulation of ubiquitination-independent mitophagy in the cells carrying the LHON-associated ND1 3460G>A or ND6 14484T>C mutation (65, 66).