HSPA1A and type 2 diabetes mellitus: We assessed the HSR via heat-challenged whole-blood samples from high-fat diet mice and discovered that ΔHSP70 expression = (HSP70 at 42 °C) – (HSP70 at 37 °C) fits a five-parameter logistic (5PL) regression with the progression of insulin resistance and predicts the onset of type-2 diabetes.