NLRP3 and obesity due to melanocortin 4 receptor deficiency: Furthermore, HSR failure in obesity is linked to increased low-grade inflammation, including activation of JNKs [16,96,97] and NLRP3 inflammasome persistence [98–100], where HSP70 serves as a negative regulator of both JNKs [24] and NLRP3 inflammasome activation [101].