INS and diabetes mellitus: Although C57BL/6J mice receiving an HFD can be accepted as a model of IR and diabetes, we observed that there were no significant differences in fasting blood glucose (Figure 10a), fasting insulin levels (Figure 10c), QUICK index (Figure 10e), HOMA (Figure 10g) or incremental area under the curve for oral GTT (Figure 12c) at the end of the study (22nd week).