Aberrant protein aggregation is a crucial pathological hallmark for diagnosis and classification of NDDs, such as accumulation of β-amyloid (Aβ) and hyperphosphorylated Tau (p-Tau) in AD, aggregation of α-synuclein (α-syn) in PD, and deposition of mutant huntingtin (mHTT) in HD [142–145]. This evidence concerns the gene MAPT and Alzheimer disease.