COL11A1 and breast carcinoma: In addition to being positively correlated with other prognostic ECM proteins such as COL11A1 [140], serum levels of α1 chain of collagen types X and XI are elevated in both benign breast disease (n = 42) and breast cancers (n = 52) compared to healthy controls (n = 50) by ELISA assays [55, 140].