NPPA and Sepsis: Moreover, in two separate studies, Gille and colleagues demonstrated that mid-regional pro-adrenomedullin (MR-proADM) and mid-regional pro-atrial natriuretic peptide (MR-proANP) may serve as diagnostic markers for the onset of sepsis in this vulnerable demographic [129, 130]. Although these biomarkers show potential, reliable and consistent predictors of burn-induced sepsis remain elusive, underscoring the need for further research.