In 2019, Yu TX et al. reported that overexpression of the lncRNA H19 can inhibit autophagy in mucositis [280]. Similarly, upregulation of another lncRNA, MANTIS, was found to inhibit autophagy in HUVECs injury in chronic kidney disease [182]. Additionally, lncRNA LINC00987 was shown to suppress autophagy in BEAS-2B cells during studies of chronic obstructive pulmonary disease [183]. Conversely, lncRNAs have also been observed to promote autophagy in the context of periodontitis. This evidence concerns the gene H19 and periodontitis.