PCSK9 and Sepsis: Here, we identified seven upregulated lipid metabolism genes in circulating leukocytes in HYPO sepsis patients, namely, PCSK9, DHCR7, LDLR, ALOX5, PLTP, FDFT1, and MSMO1. Three (PCSK9, LDLR, and PLTP) are involved in endotoxin clearance [37–[39].