Here, we identified seven upregulated lipid metabolism genes in circulating leukocytes in HYPO sepsis patients, namely, PCSK9, DHCR7, LDLR, ALOX5, PLTP, FDFT1, and MSMO1. Three (PCSK9, LDLR, and PLTP) are involved in endotoxin clearance [37–[39]. This evidence concerns the gene DHCR7 and Sepsis.