Analysis of tumor tissues showed significant downregulation of RBM15, KLF1, and ANXA8, along with reduced m6A content (p < 0.01, Fig. 9E–G), while TRIM13 expression was increased (p < 0.01, Fig. 9E, F) in the sh-RBM15 group compared to the sh-NC group. The gene discussed is ANXA8; the disease is neoplasm.