In addition, the proteins found to be altered in the ONE cells and PBMCs from BD individuals compared to controls, were significantly linked to pathways involved in cell adhesion, migration, and cytoskeletal dynamics, including ‘RhoA Signaling,’ ‘PAK Signaling,’ ‘Integrin Signaling,’ and ‘Actin Cytoskeleton Signaling’ (Fig. 3A; Supplemental Tables 2, 8). This evidence concerns the gene RHOA and Behcet disease.