Compared with normal mice (−K/BxN serum −HFD), mature B cells (CD19+B220+IgD+IgM+) (P < 0.05) and the number of Peyer’ s patches (P < 0.001) in atherosclerosis mice (−K/BxN serum + HFD) significantly decreased, but the B1 cells and immature B cells (CD19+B220+IgD−IgM−) displayed no significant differences (Fig. 8A–C). The gene discussed is CD19; the disease is atherosclerosis.