Flow cytometry analysis indicated that compared with arthritis mice (+ K/BxN serum-HFD), the amount of Th17 (CD4+IL-17+) lamina propria lymphocytes of arthritis mice combined with atherosclerosis (+ K/BxN serum + HFD) were significantly increased and Treg (CD4+FoxP3+) lamina propria lymphocytes were significantly decreased. This evidence concerns the gene CD4 and Arthritis.