IL17A and arthritic joint disease: Among arthritis mice combined with atherosclerosis (VPA, + K/BxN serum + HFD) and arthritis mice (VPC, + K/BxN serum-HFD) were 3652 DEGs, with 2120 up-regulated genes and 1532 down-regulated genes, which mainly participated in IL-17 signaling pathway (P value < 0.05) (Fig. 7B).