The results indicated that compared with arthritis mice (+ K/BxN serum −HFD), arthritis mice combined with atherosclerosis (+ K/BxN serum + HFD) significantly increased the CD3+/CXCR3+ cells (P < 0.05), CD68+ macrophages (P < 0.001), CD3+ T cells (P < 0.05). The gene discussed is CXCR3; the disease is Arthritis.