All the results of lamina propria lymphocytes concluded that HFD increased the CD3+/CXCR3+ cells, CD68+ macrophages, CD3+ T cells in lamina propria lymphocyte in arthritis mice combined with atherosclerosis, altered the ratio of Th17/Treg, disrupted the intestinal homeostasis, and the intestinal immunity was influenced through the altered gut barrier function. This evidence concerns the gene CXCR3 and arthritic joint disease.