Between arthritis mice combined with atherosclerosis (+ K/BxN serum + HFD) and arthritis mice (+ K/BxN serum-HFD), there were significant differences, however, between atherosclerosis mice (−K/BxN serum + HFD) and normal mice (−K/BxN serum-HFD), the differences were not significant, including aortic CD68+ macrophages, serum cytokines of Eotaxin, MCP-1 and IL-6, B1 cells of PP, Th17 cells, Treg cells, CD3+/CXCR3+ cells, CD68+ macrophages, CD3+ T cells of LP. The gene discussed is CCL2; the disease is arthritic joint disease.