The molecular mechanisms underlying skin fibrosis in SSc remain unclear but are likely to involve several molecules and signaling pathways, with the TGF-β signaling pathway playing a central role (Varga and Pasche 2009; Heim et al. 2022; Wei et al. 2012; Denton et al. 2018; Dees et al. 2011). This evidence concerns the gene TGFB1 and systemic sclerosis.