The essentiality of fibroblast HSP47 expression for postinjury recovery and repair was established recently by Molkentin and coworkers who demonstrated that fibroblast‐specific HSP47 deficiency causes inadequate scar formation, ventricular rupture and death after acute myocardial infarction (AMI) in mice [11]. The gene discussed is SERPINH1; the disease is myocardial infarction.