NAP-induced down-regulation of various ER stress genes in males, including those encoding the pro-neuroinflammatory Nkd2 [37], Hsph1 (Hsp110/105) and Fam107a (DRR1), which were shown to exacerbate cerebral ischemia [38], and Mertk, the mediator of alpha-synuclein fibril uptake [39]. This evidence concerns the gene NKD2 and brain ischemia.