Adnp haploinsufficiency (Adnp+/−, ICR background) or CRSIPR/Cas9 editing to generate the most prevalent neurodevelopmental ADNP syndrome mutant, i.e., the mouse equivalent p.Tyr718* (heterozygous Tyr mice with a C57BL6/NJ background) showed dramatic reduction in BrdU incorporation, resulting in mutated females that presented higher BrdU labeling than males (*P < 0.05, Tyr mice, Fig. 1F). Here, ADNP is linked to ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder.