ADNP and ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder: We further identified the growth regulator AKT, that in turn controls WNT signaling, as a key protein controlled by Adnp haploinsufficiency [21] that is accentuated in female spleens in mice heterozygous for the mouse p.Tyr718* homologue of the most abundant ADNP syndrome mutation, p.Tyr719* (Tyr mice [22]).