ADNP and early-onset autosomal dominant Alzheimer disease: Indeed, mutations and aberrations in ADNP expression are associated with stress, autism, intellectual disability (ADNP syndrome, also known as Helsmoortel Van Der Aa syndrome), cognitive dysfunction, Alzheimer’s disease [6, 9, 13, 14], and schizophrenia [15], as well as Parkinson’s disease [16] and muscle disorders [17], showing sexual dichotomy in humans [14, 15, 17, 18] and mouse models [17, 19–23] and emphasizing the importance of identifying mechanism of action and interactions of ADNP.