Intron variant of LRPPRC (Leucine-Rich Pentatricopeptide Repeat Containing) and PRCC (Proline-Rich Mitotic Checkpoint Control Factor) may partially explain abnormally high expressions of splicing regulators, as LRPPRC is an RNA-binding protein and functions in RNA polyadenylation, transport, and stability; it serves as a pan-cancer prognostic biomarker21. The gene discussed is LRPPRC; the disease is cancer.