Notable SCGs were identified with functions in nucleic acid metabolism (CHD1L, XDH, POLQ, MTHFSD, NAP1L1), DNA methylation (DNMT3A), the mucosal barrier (MUC16), transcription (SALL2, LYAR), the cell cycle (MKI67, FBXW12), multidrug resistance-associated drug pump (ABCB1), and tumor suppressor for other types of cancers (DIDO1). This evidence concerns the gene DNMT3A and cancer.