Notable SCGs were identified with functions in nucleic acid metabolism (CHD1L, XDH, POLQ, MTHFSD, NAP1L1), DNA methylation (DNMT3A), the mucosal barrier (MUC16), transcription (SALL2, LYAR), the cell cycle (MKI67, FBXW12), multidrug resistance-associated drug pump (ABCB1), and tumor suppressor for other types of cancers (DIDO1). Here, XDH is linked to cancer.