The 35 AI SCG list is a mix of (i) well-known CRC-related genes (APC, NDRG1, ABCB1), (ii) known oncogene/tumor suppressor/cancer-influencing genes in other types of cancers but not well-investigated in CRC (CRTC2, SETBP1, NRXN1, COL4A4, LRPPRC, NEGR1, EDEM1, LAMA2, PRKN, PRCC, CLPB, LAMA1, MYH11, RIMS1, RAD52), and (iii) under-investigated genes (the remaining 17 genes). The gene discussed is COL4A4; the disease is cancer.