Examples include DNA methyltransferase DNMT3A39; DNA repair enzyme POLQ40; mitotic marker and mitotic chromosome-coating surfactant MKI6741; a myeloproliferative disease suppressor DIDO142; a mediator complex subunit MED143; a tumor suppressor TP5344; nuclear lamin LMNA45; a transcriptional regulator ZBTB2446; a tumor suppressor APC47; a centrosome regulator NDRG148; an E3 ubiquitin ligase PRKN49; and a DNA repair protein RAD5250. Here, LIG4 is linked to myeloproliferative disorder.