With exceptions of 7 genes with well-demonstrated involvements in CRCs (>10 CRC-related publications; i.e., BMPR1A, MED1, TP53, SI, ATP2A3, LMNA, STAT6), most (31 of 38) of the AA-variant SCGs were under-reported with limited numbers of publications (Supplementary Table 2). Here, MED1 is linked to colorectal carcinoma.