MDM4 and neoplasm: For example, we noted a consistent reduction of gene expression of EZH2 and CUX1, which are two major tumor suppressors and frequent targets of mutations and focal deletions on 7q in a variety of myeloid neoplasms, while elevated expression was observed for several oncogenes on 1q, such as AKT3, BCL9, NCSTN, LAMC1, MDM4, and RIT1 (Supplementary Fig. 2B).