OGG1 and neuroblastoma: Similar mild leading strand bias was observed for G > T substitutions in untreated MUTHY-/- and OGG1-/- neuroblastoma cells (Supplementary Fig. 17B) that are defective in 8-oxoG repair, indicating a general better bypass of 8-oxoG on the lagging strand independent of the chemical species creating the lesion or cell type context.