In order to determine if d-monobodies can bind to full-length BCR::ABL1 in the context of the complex proteome of human cells, we performed pulldown experiments with the biotinylated l- and d-DAM21/27 variants in three biological repeats from lysates of the BCR::ABL1-expressing cell line K562, one of the most commonly used cell lines in CML research, followed by quantitative proteomics analysis of bound proteins. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.