In order to determine if d-monobodies can bind to full-length BCR::ABL1 in the context of the complex proteome of human cells, we performed pulldown experiments with the biotinylated l- and d-DAM21/27 variants in three biological repeats from lysates of the BCR::ABL1-expressing cell line K562, one of the most commonly used cell lines in CML research, followed by quantitative proteomics analysis of bound proteins. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.