TLR7 and COVID-19: We investigated the presence of: (i) potentially causal rare variants within the TLR7 locus, including adjacent non-coding regions, and in additional 13 candidate genes; (ii) monogenic conditions that might increase the risk for severe COVID-19; and (iii) immune-relevant gene sets (in both coding and non-coding regions) that are enriched for functionally-relevant rare variation.