Among several chemoattractants and their receptors, CXC chemokine ligand 12 (CXCL12) also known as stromal-cell derived factor 1 (SDF-1) and its receptor CXC type 4 (CXCR4) are involved in the proliferation and migration of GBM cells. This evidence concerns the gene CXCL12 and glioblastoma.