The MAO-A-dependent accumulation of reactive oxygen species (ROS) in prostate cancer cells stabilizes hypoxia-inducible factor 1-alpha (HIF1α), which in turn activates vascular endothelial growth factor (VEGF) and its neuropilin-1 receptor (NRP1) leading to stimulation of the Akt/FOXO1 pathway. Here, HIF1A is linked to Familial prostate cancer.