CYP2C8 and chronic myelogenous leukemia, BCR-ABL1 positive: Therefore, this study aims to evaluate the influence of CYP2C8*3 (G416A; rs11572080) and ABCG2 C421A (rs2231142) single nucleotide polymorphisms (SNPs) on plasma trough concentration and therapeutic response to imatinib in Egyptian patients with CML.