RIC8B and Parkinson disease: In order to target PTBP1 in astrocytes or neurons of 6-OHDA-induced PD mice, we designed adeno-associated virus (AAV) vectors expressing the SpG-ABE8e variant under the control of the astrocyte-specific short GFAP promoter (Lee et al., 2008) (hereafter referred to as AAV-GFAP), or the neuron-specific human synapsin 1 promoter (hsyn) (Kügler et al., 2003) (hereafter referred to as AAV-hsyn).