RIC8B and Parkinson disease: Analysis of striatum tissues isolated from AAV-ctrl- and AAV-hsyn-treated PD mice revealed base editing at the Ptbp1 splice site (AAV-ctrl, 0.4 ± 0.1%; AAV-hsyn, 23.0 ± 6.6%; Figure 3—figure supplement 2) and downregulation of Ptbp1 transcript (AAV-hsyn, 30.8 ± 14.6%, P=0.0681) and PTBP1 protein levels (AAV-hsyn, 22.1 ± 6.4%; Figure 3—figure supplement 2).