TNF and leishmaniasis: For the THP1-Xblue cell line, enrichment of pathways related to the immune system activity (NF-kappa B signaling pathway, TNF signaling pathway, chemokine signaling pathway, and cytokine–cytokine receptor interaction) and viral or protozoan infection (hepatitis B, leishmaniasis, Kaposi sarcoma-associated herpes virus infection, viral carcinogenesis, and viral protein interaction with cytokine and cytokine receptor) was observed.