Notably, the induction of de novo lipogenesis genes and lipid formation genes and the inhibition of fatty acid oxidation genes were consistently observed in the livers of ZLKO mice after HFD feeding, MASH diet feeding and oncogene‐driven HCC progression (Figures 4c,d and S2h–j), indicating that ZBTB7B expression in the liver is required for the suppression of de novo lipogenesis and activation of fatty acid oxidation in the liver, which are considered protective mechanisms for MASLD development and HCC progression. The gene discussed is ZBTB7B; the disease is hepatocellular carcinoma.