To determine whether Zbtb7b expression cell‐autonomously mediates hepatic cell proliferation and migration under both premalignant and malignant conditions, we used the normal hepatocyte cell line AML12 and the HCC cell lines Huh7 and HepG2 to establish stable ZBTB7B‐overexpressing cell lines. Here, ZBTB7B is linked to hepatocellular carcinoma.