Furthermore, the plasma NEFA, TG, cholesterol and hepatic triglyceride, and cholesterol levels were significantly increased in the Akt/N‐Ras‐induced HCC model (Figure S2f–g), suggesting that increased lipid accumulation in the livers of Zbtb7b knockout mice may also promote HCC progression in an oncogene‐induced HCC model. The gene discussed is ZBTB7B; the disease is hepatocellular carcinoma.