Studies have shown that Zbtb7b knockout promotes oncogene‐induced tumor formation by activating the c‐Jun, Erk and NF‐κB pathways (Chen et al., 2022; Xia et al., 2021; Zhu et al., 2024), whereas our study revealed that fatty acid synthesis controlled by Zbtb7b plays a critical role in MASLD‐related HCC, probably in synergy with known Zbtb7b‐regulated pathways in driving tumor initiation and progression. This evidence concerns the gene JUN and neoplasm.