TMBIM4 and Alzheimer disease: We previously reported that the inhibition of the ER/MAM‐resident sigma‐1 receptor (S1R) downregulated MAM levels, and severely reduced (∼90%) axonal but not somal Aβ generation in a neural model of AD (FAD [familial AD] hNPCs, also called ReN‐GA) in three‐dimensional (3D) dual‐chamber microfluidic devices.9, 10