Both subunits bind to each other to form the bioactiveIL-12 (IL-12p70).54 As IL-12p40 (evaluatedin this study) is also part of the cytokine IL-23, which is involvedin TH17 responses and psoriasis pathophysiology, the reduction ofIL-12p40 levels after the treatment with HF could lead to IL-17 decreasingby IL-23 reduction. Here, SPRR2A is linked to hydrops fetalis.