HCAR2 and Alzheimer disease: Other medications with negative coefficients associated with a non-T2D or AD state were isradipine, used for hypertension (CACNA1S, CACNA1C, CACMA1F, CACMA1D, and CACMA2D1 targets), niacin used for vitamin B (HCAR2 and HCAR3 targets), and disopyramide used for irregular heartbeats (SCN5A gene target) (Supplementary Table S2).