ADARB2 and early-onset autosomal dominant Alzheimer disease: For example, at the ADARB2/ADARB2-AS1 locus on chr10, which has been previously shown to be differentially methylated in Alzheimer’s disease (Konki et al., 2019), we identified methQTL-associated methylation in iPSCs that was fully unmethylated in PBMCs and vice-versa (Fig. 6A).