To gain insights into the potential roles of HK2 in tumour malignancy, particularly in cervical cancer and oral squamous cell carcinoma (OSCC), databases from the Cancer Genome Atlas (TCGA) and the National Cancer Institute’s Clinical Proteomic Tumour Analysis Consortium (CPTAC) were used to analyse the transcriptional expression and protein level of HK2. The gene discussed is HK2; the disease is oral cavity squamous cell carcinoma.