FAS and hepatocellular carcinoma: Using human hepatoma cell lines, HepG2, HLF, and HAK-1B, as well as the human neuroblastoma cell line IMR-32, Selvendiran et al. [263] reported the protective ability of luteolin against cancer through the mechanism of increasing CD95 (cluster of differentiation 95) expression in neoplastic cells in vivo and in vitro, promoting phosphorylation of signal transducer and activator of transcription 3 (STAT3) through a ubiquitination-dependent process; and was able to significantly inhibit the growth of human HCC xenografts in nude mice.