TNF and hepatocellular carcinoma: Quercetin induces apoptosis through activation of the mitochondrial pathway (caspase cascade) and by inhibiting signals in the human hepatoma cell line - HepG2 [120], disrupts the Akt/PKB pathway by inhibiting the proliferation process and induces apoptosis [121], increases TNF-related cytotoxicity apoptosis-inducing ligand (TRAIL-anticancer drug) by activating caspases and inhibiting Akt phosphorylation [122] and induces the apoptotic pathway in MCF-7 cells [123].