Hispidulin is also reported to activate AMP-activated protein kinase (AMPK), thereby suppressing eukaryotic initiation factor 4E-binding protein (4E-BP1) via the rapamycin (mTOR) pathway in glioblastoma multiforme (GBM) cells, one of the most common and deadly types of brain cancer [178]. The gene discussed is EIF4EBP1; the disease is glioblastoma.