STAT3 and Familial prostate cancer: The anticancer activity of acacetin is reported by its ability to inhibit cell growth and induce apoptosis in gastric carcinoma cells [206], inhibit the migration of MDA-MB-231 and T47D cells in breast cancer [207], inhibit the activity of signal transducer and activator of transcription 3 (STAT3) in prostate cancer [208], inhibit the invasion and migration of A549 cells in lung cancer through inhibiting the phosphorylation of Jun N-terminal kinase 1 and 2 (JNK1/2), reduction of activator protein-1 (AP-1) and nuclear factor kappa B - NF-κB [209].