MGMT and neoplasm: Regarding the relationship between the percentage of MGMT methylation and cortical/subcortical localization, our results were coherent with Han et al.’s finding that MGMT-methylated GBMs are associated with a more frequent sparing of the subventricular zone, although they did not investigate specific anatomical or lobar locations of tumours.18 Previous works have pointed out the lower survival of patients harbouring SVZ-contacting GBMs,43-47 which is coherent with our finding that deep-seated tumours have a significantly lower percentage of MGMT promoter methylation.